The Ultimate Anti-Ageing Formulation

Ceratiq®
+21 skin hydration | –18% wrinkle depth¹
Boisnic S, et al. J Cosmet Dermatol. Dec 2019;18(6):2027–2036.
Randomized, double-blind, placebo-controlled study with 64 women (average age 55.8 years) who received 350mg CERATIQ daily for 12 weeks. The results showed: significantly improved facial skin hydration from week 4, a reduction in the Lemperle wrinkle score by 1 grade by week 12, improved skin radiance and reduced roughness. 95% of subjects showed increased skin hydration compared to placebo.

CoQ10Vital®
+70% skin smoothness | –25% loss of elasticity | 6-fold bioavailability²
Žmitek K, et al. Biofactors 2017;43(1):132–140
Randomized, double-blind, placebo-controlled study with 33 healthy participants who received 50mg or 150mg CoQ10 (Q10Vital®) daily for 12 weeks. The results showed: 70–82% improvement in skin smoothness (blinded expert assessment), significant reduction in wrinkles and microrelief lines, and prevention of seasonal loss of elasticity (placebo lost ~25% elasticity, while CoQ10 groups maintained elasticity). Both doses were effective. Self-assessment also showed improved skin firmness.

SkinAx²™
+26% skin radiance | –19% dark circles | +13% even skin tone | –19% redness | –21% spots³
Dumoulin M, et al. Clin Cosmet Investig Dermatol 2016;9:315–324
Clinical study under dermatological control with 35 women aged 40 to 70 with a dull complexion. The participants received 150mg SkinAx²™ daily for 2 months. Using both objective (cutometer, sensory assessment) and subjective methods, 82% of women achieved a more even complexion and brighter skin – with significant improvements in color, contrast and imperfections. Two out of three women said they looked better after taking the supplement.

Theracurcumin ®
76% clinical efficacy | Reduced joint pain and stiffness | 27-fold bioavailability⁴
Nakagawa Y, et al. Clin Med Insights Arthritis Musculoskelet Disord. 2020;13:1179544120948471.
A 6-month prospective study of 45 patients with knee osteoarthritis who received Theracurmin® (180mg curcumin/day). The results showed that 76% of patients experienced clinically significant improvements in pain and joint function. VAS pain scores, JKOM scores and JOA scores all improved significantly from baseline (p <0.05). Clinical benefits occurred within 1–2 months and persisted for 6 months. Theracurmin®® has a 27-fold higher bioavailability than conventional curcumin powder. No significant side effects were observed.

R-Alpha Lipoic Acid (bioenhanced)
–25% oxidative stress | +22% antioxidant activity⁵
Bobe G, et al. J Nutr. 2020;150(9):2336–2345.
Randomized, double-blind, placebo-controlled study of 81 adults who received 600mg of R-lipoic acid daily for 24 weeks. The results showed: 25% reduction in F₂ isoprostanes (marker for oxidative stress), 22% increase in HMOX1 antioxidant gene expression, 10.1% reduction in leukocytes in the blood and 7.4% reduction in the inflammation marker ICAM-1.

Theracurcumin®
Improvement of knee osteoarthritis
Nakagawa Y, et al. J Orthop Sci. 2014.
Randomized, double-blind, placebo-controlled study with 50 patients with knee osteoarthritis. Theracurmin significantly reduced VAS scores for knee pain after 8 weeks compared to placebo (in patients with a baseline score of >0.15) and significantly reduced celecoxib dependence without serious adverse events.

Ceratiq®
Significantly improved skin hydration
Guillou S, et al. Int J Cosmet Sci 2011;33(2):138–143
Double-blind, randomized, placebo-controlled study with 51 women aged 20 to 63 years with dry to very dry skin. The participants received 350mg of wheat extract oil (rich in ceramides and digalactosyl diglycerides) daily for 3 months. Skin hydration on arms and legs was significantly increased compared to placebo. 95% of women in the treatment group showed increased skin hydration. Skin dryness, roughness and redness were reduced. The product was well tolerated and there were no side effects.

Astaxanthin (AstaReal®)
Prevents skin ageing | Protects moisture and elasticity
Tominaga K, et al. J Clin Biochem Nutr. 2017.
Randomized, double-blind, placebo-controlled study of 65 healthy women who received 6mg or 12mg of AstaReal astaxanthin daily for 16 weeks. Results showed that wrinkle parameters and skin hydration worsened significantly in the placebo group but were maintained in the astaxanthin groups, while astaxanthin suppressed UVB-induced IL-1α and MMP-1 secretion and protected the skin from seasonal deterioration.

Astaxanthin (AstaReal®)
Improved skin elasticity and fine lines | Increased skin hydration and smoothness
Yamashita E. Carotenoid Science. 2006;10:91–95.
Randomized, double-blind, placebo-controlled study in 49 healthy adult women (45–50 years) who received oral astaxanthin (4mg/day) for 6 weeks. The results showed a significant improvement in skin elasticity and fine lines/wrinkles as assessed by dermatology, an increase in skin hydration levels as measured by instruments and improvements in skin texture/smoothness parameters compared to baseline/placebo, suggesting an overall improvement in skin condition with astaxanthin supplementation.

Astaxanthin (AstaReal®)
–21.7% reduction in oxidative stress | Improved desquamation and skin surface quality
Chalyk NE, et al. Nutr Res. 2018;48:40–48.
Open-label intervention study in 31 middle-aged men and women (>40 years) who took 4 mg of astaxanthin daily for 4 weeks. Results showed a reduction in plasma malondialdehyde (marker of oxidative stress) by 11.2% on day 15 and by 21.7% on day 29 compared to baseline, along with a significant reduction in corneocyte desquamation and microbial presence in residual skin surface components, suggesting improved skin surface morphology and reduced oxidative stress with continued astaxanthin intake.

Lutemax® 2020 (Lutein & Zeaxanthin)
Improved macular pigment and visual performance | Reduced eye strain, headaches and improved sleep quality
Stringham JM, et al. Invest Ophthalmol Vis Sci. 2017;58(9):3879–3888.
Randomized, double-blind, placebo-controlled study in healthy adults who were administered 24mg of macular carotenoids from Lutemax® 2020 daily for 6 months. Results showed a significant increase in macular pigment optical density compared to placebo, significant improvements in contrast sensitivity, glare sensitivity and recovery from light stress and visual performance in bright light conditions, along with a significant reduction in eye strain, eye fatigue and headache frequency while improving overall sleep quality.

Lutemax® 2020 (Lutein & Zeaxanthin)
Improved skin tone and luminosity | Increased light protection and skin brightening
Juturu V, et al. Clin Cosmet Investig Dermatol. 2016;9:325–332.
Randomized, double-blind, placebo-controlled study of 46 healthy adults (18–45 years, Fitzpatrick skin types II–IV) who received 10mg lutein + 2mg zeaxanthin isomers (Lutemax® 2020) daily for 12 weeks. Results showed significant improvements in overall skin tone, increased skin luminosity, decreased skin laxity, increased individual typological angle (indicating measurable skin lightening), increased minimal erythemal dose (better UV light protection), and improved skin firmness and elastic recovery compared to placebo.

LycoBeads® (Tomato Lycopene Complex)
Reduced bone resorption markers and supported bone formation in postmenopausal women
Meeta M, et al. J Midlife Health. 2022;13(1):50–56.
Randomized, double-blind, placebo-controlled study at 21 centers in India with 100 healthy postmenopausal women who were given 8 mg LycoRed (antioxidant power equivalent to 24 mg lycopene) or placebo daily for 6 months. Supplementation resulted in a significant increase in serum lycopene compared to placebo, a favorable directional change with increased bone formation marker P1NP and a reduction in bone resorption marker β-CTx, and a higher proportion of women achieving a significant reduction in β-CTx (46% versus 33% on placebo), in addition to a significant reduction in hs-CRP and no supplement-related adverse events.

LycoBeads® (Tomato Lycopene Complex)
Reduced oxidative stress and bone resorption in postmenopausal women
Mackinnon ES, et al. Osteoporos Int. 2011;22(4):1091–1101.
Randomized, double-blind, placebo-controlled study in postmenopausal women who received lycopene or placebo for 4 months. The results showed a significant reduction in oxidative stress parameters and serum N-telopeptide, a marker of bone resorption, compared to placebo, supporting the protective effect of lycopene against bone loss in postmenopausal women.

LycoBeads® (Tomato Lycopene Complex)
Protection against UV-induced light ageing of human skin
Grether-Beck S, et al. Br J Dermatol. 2017;176(5):1231–1240.
Double-blind, randomized, placebo-controlled, crossover study in 65 healthy adults who received a lycopene-rich tomato nutrient complex or a placebo for 12 weeks. After supplementation, UV-irradiated skin showed complete prevention of UV-induced increases in HO-1, ICAM-1 and MMP-1 mRNA expression compared to placebo, demonstrating molecular protection of human skin against UV-induced oxidative stress, inflammation and collagen degradation associated with photoaging.